The student's Internal Assessment (IA) demonstrates a focused and detailed description of the main topic, with a clear statement of the study's aim and a well-structured research question. The background information provided is relevant and focused, offering a clear explanation of the diseases studied and their link to the hypoxic state. The biological basis of the diseases is well-explained and supported by scientific findings. Additionally, the methodology of the investigation is highly appropriate to the topic, as the student correctly identifies the independent and dependent variables to pursue the research question. However, it is important to note that the methodology lacks appropriate steps to assure the relevancy and validity of the obtained results, as the controlled variables are not listed.